Functional Analysis of Heat Shock Transcription Factors by Generating Knockout Mice
نویسندگان
چکیده
منابع مشابه
Regulation of the heat shock response by heat shock transcription factors
The heat shock response is characterized by a rapid and robust increase in heat shock proteins upon exposure to protein-damaging stresses. This evolutionarily conserved cellular protection mechanism is primarily regulated at the level of transcription. In bacteria, heat shock-induced transcription is regulated by the activation of σ factor, whereas eukaryotes utilize heat shock transcription fa...
متن کاملRoles of the heat shock transcription factors in regulation of the heat shock response and beyond.
The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or chronic stress. Hsps function as molecular chaperones in regulating cellular homeostasis and promoting survival. If the stress is too severe, a signal that leads to programmed cell death, apoptosis, is activated, there...
متن کاملFunctional Characterization of Fission Yeast Transcription Factors by Overexpression Analysis
In Schizosaccharomyces pombe, over 90% of transcription factor genes are nonessential. Moreover, the majority do not exhibit significant growth defects under optimal conditions when deleted, complicating their functional characterization and target gene identification. Here, we systematically overexpressed 99 transcription factor genes with the nmt1 promoter and found that 64 transcription fact...
متن کاملInhibition of heat shock transcription factor by GR.
The GR is a hormone-activated transcription factor that acts to regulate specific gene expression. In the absence of hormone, the GR and other steroid receptors have been shown to form complexes with several mammalian heat shock proteins. As heat shock proteins are produced by cells as an adaptive response to stress, speculation has existed that communication between the heat shock and glucocor...
متن کاملTranscription Regulation of HYPK by Heat Shock Factor 1
HYPK (Huntingtin Yeast Partner K) was originally identified by yeast two-hybrid assay as an interactor of Huntingtin, the protein mutated in Huntington's disease. HYPK was characterized earlier as an intrinsically unstructured protein having chaperone-like activity in vitro and in vivo. HYPK has the ability of reducing rate of aggregate formation and subsequent toxicity caused by mutant Hunting...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Yamaguchi Medical Journal
سال: 2006
ISSN: 0513-1731,1880-4462
DOI: 10.2342/ymj.55.11